‘Til tide’s edge touches sand Or beyond it, ankle-deep? Will it roll in Or ebb out? Will it slap me Or dupe me, send me chasing it? And the current – Will I feebly float or will my feet be knocked from under me? Under me. Down…under water, Out to sea… How long will I...
Stuck my hand into A pocketful of glass Smoothed by the sand Dulled by the sea. They fail to understand How I withdraw my hand Unharmed. They stare in alarm, Concerned, as if I'd been maimed, Or burned. I wonder the same, Unimpressed, and recall that Sharp shards of...
It's now five months since the loss of our MaryAnne DiCanto. Missing you every moment my darling. Five months without you baby and still stuck. As promised, I'm trying to get better. But I don't know what better should feel like. Books on the subject suck and...
Today was a busy day for The Tutu Project! We met with metastatic breast cancer patient advocacy leaders at AstraZeneca’s roundtable meeting to discuss the challenges the community faces and ways to collaboratively address patient needs. After the meeting, we joined...
One of my favorite aspects of my work is when someone shares their story with me. Thank you, Amy. I know your words will help inspire others diagnosed with this disease. I hate pink; always have. I always thought it was too foofy, too predictable, too 'girly.' Then...
When I was diagnosed with breast cancer, Bob and I had just moved to Brooklyn, NY. We are self-employed and at that moment, we still needed clients to build our business. I need to stress the 'still' because we were just re-starting our business. So we needed work,...
vul·ner·a·ble ˈvəln(ə)rəb(ə)l/ What I become when my friend Jennifer invites me to and holds my hand while doing so as only a friend can do. Join me as I speak about myself, and living with breast cancer. I lessen my grip on the words hiding in the dark; words that on...
Affordable Ways of Inspiring Cheer Epigenetic research and modern medicine support the claim that laughter is often the best medicine. Research has shown that individuals with a deeper sense of happiness possess lower levels of inflammatory gene responses and...
Breast Cancer Stories
Stories, sidenotes, rants, & raves.
When a loved one faces a cancer battle, your world goes dark. Goals are hard to set and the concept of a tomorrow becomes a frightening one. So when that dark and frightening world got infiltrated by a ‘naked man’ in a pink tutu, it shined a little ray of light and put a little smile on our faces and that, in turn, made this fight more bearable. So for that, The Tutu Project will always hold a special place in our lives.
How I found the lump that led to a Breast Cancer diagnosis When I was 32, I found a lump in my right breast. I remember exactly where I was at that moment. I was on my couch; not sure how or why my hand brushed against my breast but it did and once I felt it I...
In June 2001, I will never forget the day I was diagnosed with breast cancer. When I received the call, I was working. After hearing those words, “You have breast cancer”, I went outside, layed on the grass, stomped my feet and cried. The first question that came to...
Do you ever have days that you just want to give into breast cancer? By this, I don't mean to give in completely, I mean for more than a few moments in the day. What would it be like to give into the fatigue, the emotions and the unending positive vigil? No...
Behind the Scenes
The stories behind the images
The Carmelite Monastery is where the Santa Fe Photography Workshops is held throughout the year. I have been going there since 1996 and those workshops pretty much changed my life by introducing me to the most, talented photographers and students I have ever met....
It's been amazing how one person willing to give us an opportunity hoping to help our breast cancer cause has led to another. If you follow our stories you know that the Swan Lake image at The Metropolitan Opera House happened thanks to Dathan. And while shooting with...
This is one of those moments that make you want to ask someone to "pinch you". And not just because I am center stage at NJPAC (New Jersey Performing Arts Center) holding Trigger, one of the most famous guitars in Country Music (I am a huge Willie Nelson fan!) But...
Behind the Scenes: “Swan Lake” at the Metropolitan Opera House Dedicated to Women with Breast Cancer
Image, "Swan Lake" - The Story Social Media has always been our greatest marketing asset but we never dreamed it would lead to this. We met Dathan Manning through Facebook after Marcela (our business manager) and I posted our shoot location for "Central Park". It...
Support & Inspiration
Two months have passed since the loss of our beloved MaryAnne DiCanto. In the midst of packing mayhem, I pause to pay tribute to my darling. Such a troubling experience. Packing the house feels like the unraveling our life together. One moment chuckling over a silly...
Two weeks to the moment since we lost our MaryAnne DiCanto. The pain remains agonizing and fresh, as if it just happened. I wish I had a better answer to the question of how I'm doing. I wish I could soldier-up and suck it up. I can with all other pain, this pain...
Here is a better explanation of what is going on. Another MaryAnne DiCanto poem of sorts. Sorry everyone, turns out this is my best way of expressing the loss. These Days These days I go to bed to the sound of the birds waking up. Those hours just before sunrise when...
We invite our fans to honor their caregivers. Sometimes caregivers are the 'silent heroes' in the fight against cancer, staying strong for the men and women they love. This is an invitation to share their story - not only to honor them, but to inspire others with...
Resources for Breast Cancer Patients
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Metastatic Breast Cancer
Education & Advocacy
The HER2 Landscape Therapies Multiply HER2 is a member of a tyrosine kinase receptor family that plays a central role in cell growth, proliferation, survival, and differentiation via multiple signal transduction pathways (Figure).
The overall response rate was 30% and the clinical benefit rate was 70%.5 New Standard in the Metastatic Setting Among HER2-targeting drugs, pertuzumab has set the pace for dual HER2 blockade strategies.
It is approved in combination with trastuzumab and docetaxel for the first-line treatment of patients with HER2-positive metastatic breast cancer and as neoadjuvant therapy for patients with locally advanced or early-stage breast cancer.
Dual targeting of HER2 with these antibodies was evaluated in the phase III CLEOPATRA trial in which 808 patients were randomized to receive trastuzumab and docetaxel with either pertuzumab or placebo.
Initial results, which led to the FDA’s approval of pertuzumab in combination with trastuzumab, demonstrated a 6-month improvement in progression-free survival (PFS) in patients treated with dual HER2 blockade compared with the control group (18.5 months vs 12.4 months, respectively; HR, 0.62; P <.001), with a strong trend toward improved overall survival (OS).6 The benefit was confirmed in a final analysis of the trial, in which the level of OS attained was unprecedented in the first-line setting for metastatic breast cancer.7 CLEOPATRA heralded dual HER2 blockade as a new standard of care as firstline therapy for patients with metastatic disease who had not received chemotherapy or prior HER2 therapy in this setting. In both T-DM1 arms, PFS was noninferior, but not superior, to the control arm, although there were fewer discontinuations because of adverse events and health-related quality of life (HRQoL) was maintained for a longer period.9 The combination of neratinib with trastuzumab has been evaluated in the phase I FB-8 trial, a single-arm dose-escalation study, and resulted in significant clinical benefit in heavily pretreated patients.10 Similarly, phase Ib trial results for tucatinib in combination with trastuzumab and capecitabine demonstrated encouraging response rates among patients with metastatic breast cancer, including individuals with brain metastases.11 Those results prompted an increase in the projected enrollment in the HER2CLIMB trial testing the same triplet combination (NCT02614794). The combination of pertuzumab, trastuzumab, and docetaxel was approved by the FDA as a neoadjuvant regimen in 2013 based on the phase II NeoSphere trial. Five-year PFS rates were 86% for dual HER2 therapy and 81% for trastuzumab alone, while DFS rates were 84% and 81%, respectively.14 The combination of trastuzumab and lapatinib has also been shown to be effective in the neoadjuvant setting, based on the results of the NeoALTTO trial, in which 55 women with operable HER2-positive tumors were randomized to receive either lapatinib or trastuzumab monotherapy or a combination of the 2, followed by paclitaxel, prior to surgery. Two of the treatment arms involve dual HER2 blockade. However, 10-year ALTTO follow-up results indicated a benefit of dual HER2 blockade among patients with HR-negative breast cancer.19 In the highly anticipated APHINITY trial, 4085 patients with operable, HER2-positive breast cancer were randomized to adjuvant trastuzumab and chemotherapy with either pertuzumab or placebo.
Pfizer-led consortium begins trial of metastatic breast cancer treatment palbociclib.
From: pharmaceutical-business-review.com Pfizer, along with Alliance Foundation Trials (AFT) and six other international cancer research groups, has commenced a phase 3 clinical study to assess palbociclib (Ibrance) for the treatment of patients with metastatic breast cancer.
Patina is a randomized, open-label and phase 3 clinical trial, which will assess palbociclib in combination with anti-HER2 therapy and endocrine therapy against standard therapy as a first-line treatment for patients with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-positive (HER2+) metastatic breast cancer.
In the US, Ibrance secured approval to treat HR+ and HER2-negative (HER2-) advanced or metastatic breast cancer in combination with an aromatase inhibitor as initial endocrine-based therapy in postmenopausal women or fulvestrant in women with disease progression following endocrine therapy.
The trial will recruit women or men with HR+, HER2+ metastatic breast cancer following completion of induction with anti-HER2 based chemotherapy.
The will be randomized to one of two treatment arms after completing.
One study arm will evaluate patients with palbociclib and standard anti-HER2 therapy and endocrine therapy until disease progression, while other study arm will assess patients with standard anti-HER2 therapy and endocrine therapy until disease progression.
Around 500 patients will be enrolled in the trial across the globe.
Pfizer is offering financial support for the trial, while AFT is the global sponsor for the study being carried out in the US, Germany, Italy, Spain, Australia, and New Zealand.
Alliance Foundation Trials president and CEO Dr Monica Bertagnolli said: “The PATINA trial offers an exciting opportunity for a new global collaborative initiative among clinical trial groups aimed at improving the treatment of women with metastatic breast cancer.” Pfizer Oncology chief medical officer Dr Charles Hugh-Jones said: “Patina is the first randomized, Phase 3 trial of a CDK 4/6 inhibitor in this setting.” Facebook comments:
The Adelphi Statewide Breast Cancer Program is hosting a forum about the power of breast cancer support groups at 6 p.m. Sept. 13 at Adelphi’s Alumni House in Garden City.
Licensed clinical social worker Erin Nau, who will be facilitating the event with licensed master social worker Angela Papalia, said the organization has sponsored a host of support groups for male and female patients, survivors, caretakers and partners The Power of Support Group for Breast Cancer Patients forum, sponsored by the Junior Coalition of the Manhasset Women’s Coalition Against Breast Cancer, will feature a panel of former breast cancer support group members sharing their experience with the groups.
Nau said she and director Hillary Rutter have been researching the importance of support groups and wanted to share that information with people who have been curious about the groups but never joined.
“We thought, that is so powerful, we want to share that information with people who might be on the cusp, debating to join a support group.” Nau said the trouble with her research is the people she needs to talk to are the people who aren’t coming to the support groups.
“Sometimes what I hear from women who wait a little while to come, they don’t want to talk about it all the time,” Nau said.
Thanks to their large network, Nau said they can easily connect patients and survivors who have similar stories, interests or diagnoses.
“We ran the first men’s support group for men with breast cancer, and all of those men are thankfully survivors now and are not in the group anymore, but we would like to start one,” Nau said.
“If we had even two men reach out to us, we’d absolutely start one if the need was there.” While the support groups are geared toward patients and survivors, Nau said anyone is welcome.
“I think the biggest thing is just we want not just women who have come to support groups, but people who’ve been curious about it and social workers who are thinking about starting support groups and hospital staff,” Nau said.
“It’s not just for survivors; we’re opening it up to anyone who’s thinking about running a support group as well.” Reservations are required for the forum.
Breast Cancer Research
Latest news from around the web
Kim Cattrall Joins Stand Up To Cancer Canada And The Canadian Breast Cancer Foundation To Raise Awareness And Funds For Breast Cancer Research
Source: companiesandcausescanada.com New campaign reinforces that collaborative research bringing new treatments to breast cancer patients faster enables women to live full, active lives Stand Up To Cancer Canada (SU2C Canada) and the Canadian Breast Cancer Foundation...
Source: Breast Cancer Now A highly successful pink silage bale campaign in aid of breast cancer research is being re-launched for 2017. Stories David Neville, Managing Director of Animal Nutrition for Volac (left); Jackie Bradley, Volac Product Manager (second from...
Source: The Daily Herald Roanoke Rapids’ Rural Health Group can bolster its breast cancer awareness outreach programs even further after receiving a $45,000 grant earlier this month. The grant was awarded by the Avon Breast Health Outreach Program and Patricia Peele,...
Companies that Care
Corporate support makes us possible!
We can’t thank On Location Tours for offering to donate ALL proceeds of their November 1st Sex and the City tours to the Carey Foundation for men and women with breast cancer.
Konectidy is a company founded for the the singular purpose of “Konecting” others for their common cause. For breast cancer awareness month they are donating 30% of bracelet sales to our Foundation.
There are partnerships, that one knows from the very beginning, are the ideal fit. Bob and I believe this to be true with BlackRapid . I mean, really, what could be better? Camera straps– Bob's favorite– AND a substantial benefit for women and men living with...
Ideas + Inspiration
S.T.Art HUB – Art therapy.
Video documentativo dell’esperienza di arte terapia svoltasi durante la residenza artistica S.T.Art HUB (27.09 – 08.10.2016).
http://www.summertemporaryart.it This article was originally published at the “Article” source noted above and distributed by The Tutu Project for informational purposes only.
Art Therapy and Pain.
With Art Therapy, you can explore deep, long held fears and inner pain and turmoil that you are unable to face.
You can creatively and safely look at many issues, safely, using Art Therapy.
Sometimes words are not enough and being creative can help you think differently about your situation and open your world to different possibilities #arttherapy #issues #pain #creativity #change This article was originally published at the “Article” source noted above and distributed by The Tutu Project for informational purposes only.
Rituals Help you Heal.
It inspired me to make my own little altar every year for the people I am missing in my life.
Like a stuffed whale that my mother bought when we went whale watching, a CD with songs by my nephew, a pair of old glasses that belonged to my grandfather, stones, shells and glass beads that remind me of special times together.
There are always flowers and candles.
I will create my altar on Halloween and leave it up for a few days.
I take special care to put all the little pieces back in their usual place.
Every time I create the altar I feel the warmth and love of my loved ones around me and comforted by the notion of celebrating their lives.
Through creating we heal and are able to find new purpose.
What are your rituals that help you heal?
Share your rituals here or at www.facebook.com/healingforgrievinghearts Take good care, Jacqueline If you liked this piece and want others to find it please click on the green heart. This article was originally published at the “Article” source noted above and distributed by The Tutu Project for informational purposes only.